Antibiofouling Zwitterionic Gradational Membranes with Moisture Retention Capability and Sustained Antimicrobial Property for Chronic Wound Infection and Skin Regeneration

Abstract

Nonadherent wound dressings with moisture management and long-lasting antibacterial properties have great significance for wound healing clinically. Herein, a novel multicomponent zwitterionic gradational membrane is fabricated by a co-electrospinning method to realize low biofouling and favorable moisture control as well as long-acting antibacterial properties during the chronic wound-healing process. The obtained membrane possesses excellent anti-biofouling performance that effectively resists protein, bacteria, and cell adhesion according to in vitro antifouling evaluation. Furthermore, the gradational co-electrospinning method grants the composite membrane with moisture retention capability which could effectively absorb wound exudate and maintain a moisture healing environment. Additionally, in vivo and in vitro antibacterial investigations reflect that the composite membrane has excellent long-acting antibacterial property. Moreover, in vivo wound healing assessment confirms that the prepared membrane significantly reduces the complete wound healing time than commercial wound dressing. These results highlight such a zwitterionic gradational membrane as an advanced wound dressing to meet the various requirements for chronic wound infection and skin tissue regeneration in clinical applications.