Concepedia

Preactivation-based, iterative one-pot synthesis of anticoagulant pentasaccharide fondaparinux sodium

Hongzhen Jin, Qiang Chen, Yanyan Zhang, Kai-Feng Hao, Guoqiang Zhang, Wei Zhao

Organic Chemistry Frontiers · 2019 · 25 citations · 23 references

DOI

Concepts

Abstract

A one-pot, three-component synthetic strategy was designed to rapidly assemble fondaparinux, using a monosaccharide donor and two disaccharide acceptors.

References

23

Oversulfated chondroitin sulfate is a contaminant in heparin associated with adverse clinical events

Marco Guerrini, Daniela Beccati, Zachary Shriver et al. · Nature Biotechnology · 2008 · 617 citations

, , +7

2003 Claude S. Hudson Award Address in Carbohydrate Chemistry. Heparin:  Structure and Activity

Robert J. Linhardt · Journal of Medicinal Chemistry · 2003 · 485 citations

, , +14

Chemoenzymatic Synthesis of Homogeneous Ultralow Molecular Weight Heparins

Yongmei Xu, Sayaka Masuko, Majde Takieddin et al. · Science · 2011 · 396 citations

, , +14

The Unique Antithrombin III Binding Domain of Heparin: A Lead to New Synthetic Antithrombotics

C. A. A. VAN BOECKEL, Maurice Petitou · Angewandte Chemie International Edition in English · 1993 · 382 citations

, , +17

Iterative One‐Pot Synthesis of Oligosaccharides

Xuefei Huang, Lijun Huang, Haisheng Wang et al. · Angewandte Chemie International Edition · 2004 · 357 citations

, , +10