Concepedia

Highly enantioselective sequential vinylogous aldol reaction/transesterification of methyl-substituted olefinic butyrolactones with isatins for the construction of chiral spirocyclic oxindole-dihydropyranones

Zhen‐Hua Wang, Xia-Yan Zhang, Chuan-Wen Lei, Jian‐Qiang Zhao, Yong You, Wei‐Cheng Yuan

Chemical Communications · 2019 · 29 citations · 60 references

DOI

Concepts

Abstract

A highly stereoselective sequential vinylogous aldol reaction/transesterification of methyl-substituted olefinic butyrolactones and isatins was developed. With this developed protocol, a series of chiral spirocyclic oxindole-dihydropyranones were obtained in good to excellent yields (73-99%) and enantioselectivities (71-97% ee).

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