Concepedia

Rosiglitazone Treatment Prevents Postoperative Fibrosis in a Rabbit Model of Glaucoma Filtration Surgery

Feng Zhang, Ke Liu, Mengdan Cao, Jing Qu, Dengming Zhou, Zheng Pan, Xuanchu Duan, Yong Zhou

Investigative Ophthalmology & Visual Science · 2019 · 27 citations · 12 references

DOIFull text

Open access

Abstract

RSG treatment prevents subconjunctival fibrosis after GFS by inhibition of profibrotic gene expression through a mechanism involved in promoting autophagy in local fibroblasts. RSG represents a novel antifibrotic drug with the potential to improve the success rate of GFS.

References

12

Autophagy fights disease through cellular self-digestion

Noboru Mizushima, Beth Levine, Ana María Cuervo et al. · Nature · 2008 · 6.4K citations · Full text

, , +8

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

Nirmala Hariharan, Yasuhiro Maejima, Jun Nakae et al. · Circulation Research · 2010 · 674 citations · Full text

Effects of Pirfenidone on Proliferation, Migration, and Collagen Contraction of Human Tenon’s Fibroblasts In Vitro

Xianchai Lin, Minbin Yu, Kaili Wu et al. · Investigative Ophthalmology & Visual Science · 2009 · 115 citations

Suppression of Type I Collagen Expression by miR-29b via PI3K, Akt, and Sp1 Pathway in Human Tenon's Fibroblasts

Ning Li, Juanlian Cui, Xuanchu Duan et al. · Investigative Ophthalmology & Visual Science · 2012 · 93 citations · Full text

Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells

Zhenghai Tang, Wenxiang Cao, Zhaoyu Wang et al. · Redox Biology · 2017 · 69 citations · Full text