Double electrooxidative C–H functionalization of (het)arenes with thiocyanate and 4-nitropyrazolate ions

Abstract

The double anodic C–H functionalization of N-methyl-1H-pyrrole and N,N-dimethylaniline using both thiocyanate and 4-nitro-1H-pyrazolate ions as nucleophiles has been accomplished for the first time. The mild reaction conditions and considerable pharmacological activity of the target products make such C–S and C–N coupling strategy to be highly attractive for further applications.