Synthesis of Oxazoles, Imidazoles and Pyrroles with the Use of Mono-substituted Tosylmethyl Isocyanides

Abstract

Oxazoles, pyrroles and irnidazoles are synthesized from mono-a1 k y l ated tosylmethyl i socyanides (TosCHRN=C) and aldehydes, Michael-acceptors o r aldimines .Tosylmethyl isocyanide (TosMIC, 1, R = H) has been found a useful synthon i n organic chemistry.2Base-induced reactions o f TosMIC w i t h unsaturated substrates such as ketones, aldehydes, imines and Michael acceptors lead t o