Concepedia

<i>In Vivo</i> Effectiveness of Orlistat in the Suppression of Human Colorectal Cancer Cell Proliferation

Aleksandra Czumaj, Judyta Zabielska, Alicja Pakiet, Adriana Mika, Olga Rostkowska, Wojciech Makarewicz, Tomasz Śledziński, Ewa Stelmańska

Anticancer Research · 2019 · 35 citations · 29 references

DOIFull text

Open access

Abstract

Inhibition of CRC cell proliferation by orlistat is reversed by palmitate which is present at high levels in the serum. Therefore, orlistat may be effective in vivo only at high concentrations.

References

29

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XBP1

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, , +11

Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity

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