Regioselective <i>Ortho</i> Amination of an Aromatic C–H Bond by Trifluoroacetic Acid via Electrochemistry

Abstract

A trifluoroacetic acid-facilitated <i>ortho</i> amination of alkoxyl arene has been established via anodic oxidation in an undivided cell. In the absence of any additional metal or oxidant reagents, a series of aromatic and heteroaromatic amine derivatives have been synthesized in good to excellent yields. Our findings reveal the possibility of achieving complete <i>ortho</i>-selective amination of a simple arene, which emerges as an efficient route for facile and large-scale organic synthesis.