Conserved <i>NPPB</i> + Border Zone Switches From MEF2- to AP-1–Driven Gene Program

Abstract

Cardiomyocytes in a discrete zone bordering the infarct switch from a MEF2-driven homeostatic lineage-specific to an AP-1-driven injury-induced gene expression program. This program is conserved between mouse and human, and includes Nppb expression, which is required to prevent acute heart failure after infarction.