Design, Synthesis, and Biological Evaluation of Novel 2-(4-Arylsubstituted-1H,2,3-triazol-1-yl)-N-{4-[2-(thiazol-2-yl)benzo[d]thiazol-6-yl]phenyl}acetamide Derivatives as Potent Anticancer Agents

Abstract

A novel series of benzothiazole bearing 1,2,3-triazole derivatives 11a–11j are synthesized, and their structures are confirmed by 1H and 13C NMR, and mass spectral data. The synthesized compounds are tested for their anticancer activity towards human cancer cell lines including MCF-7 (breast), A549 (lung), Colo-205 (colon), and A2780 (ovarian) and demonstrate moderate to high activity. Among those, compounds 11b, 11c, 11d, 11e, 11f, and 11g are characterized by more potent activity than the standard drug.