EFFICIENT SYNTHESIS OF CHLORO CHALCONES UNDER ULTRASOUND IRRADIATION, THEIR ANTICANCER ACTIVITIES AND MOLECULAR DOCKING STUDIES

Abstract

Chloro chalcone derivatives 1-5 were synthesized by the conventional and sonochemical method. A significant enhancing effect in reaction time was observed in chalcones synthesis under ultrasound irradiation. Characterization of all chalcones was conducted by GC-MS, FTIR and NMR spectrometers. Anticancer evaluation displayed that chalcone 3 has high activity against breast cancer cell line MCF7 (IC50 0.8 g/mL), T47D (IC50 0.34 g/mL), cervical cancer cell line HeLa (IC50 4.78 g/mL), and colorectal cancer cell line WiDr (IC50 5.98 g/mL). Docking study revealed the interaction between chalcones and EGFR receptor through hydrogen bonds and -cation interactions. It was also observed that methoxy substituent on chalcones increased their activity as anticancer.