Synthesis and evaluation of AChE inhibitory activity of 5,6‐diaryl‐1,2,4‐triazinyloxyacetyl‐4‐substituted thiosemicarbazides, triazoles and <i>N</i>‐benzylidene derivatives

Abstract

Abstract A series of 1,2,4‐triazinyl thiosemicarbazides, triazoles and N ‐benzylidene derivatives have been synthesized by condensation of 5,6‐diphenyl‐1,2,4‐triazin‐3‐yloxyacetyl hydrazine with aromatic aldehydes and aryl isothiocyanates. Subsequent ring closure of thiosemicarbazides yielded the triazoles. All the compounds were subjected to in vitro testing of cholinesterase inhibitory action. Percentage inhibition was found to be moderate to good in a few of the compounds.