<p>Identifying risk factors for high-dose methotrexate-induced toxicities in children with acute lymphoblastic leukemia</p>

Abstract

Routine monitoring of 44-h MTX concentrations is essential to identify patients at high risk of developing febrile neutropenia and vomiting. This study may provide a reference for clinicians to distinguish patients with a relatively high risk of severe AEs based on certain characteristics before HD-MTX infusion.