Enhanced ATP release and CD73‐mediated adenosine formation sustain adenosine A<sub>2A</sub> receptor over‐activation in a rat model of Parkinson's disease - Concepedia

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Enhanced ATP release and CD73‐mediated adenosine formation sustain adenosine A<sub>2A</sub> receptor over‐activation in a rat model of Parkinson's disease

DOI Full Paper Access

48

Citations

61

References

2019

Year

Marta Regina Santos do Carmo, Francisco Q. Gonçalves, Paula M. Canas, Jean‐Pierre Oses, Francisco Diego Pinheiro Fernandes, Filipe V. Duarte, Carlos M. Palmeira, Ângelo R. Tomé, Paula Agostinho, Geanne Matos de Andrade,

British Journal of Pharmacology

Abstract

Our data indicate that increased ATP-derived adenosine formation is responsible for A<sub>2A</sub> receptor over-activation in PD, suggesting CD73 as a new target to manage PD.

References

	Year	Citations

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