Concepedia

4,5-Difluoro-1,2-dehydrobenzene: generation and cycloaddition reactions

Valery N. Charushin, S. K. Kotovskaya, Svetlana A. Romanova, Yury V. Tomilov

Mendeleev Communications · 2005 · 16 citations · 10 references

DOI

Concepts

Abstract

The oxidation of 1-amino-5,6-difluorobenzotriazole with Pb(OAc)4 in dry CH2Cl2 afforded 4,5-difluoro-1,2-dehydrobenzene, a new active intermediate, which can be used in situ for the synthesis of fluorinated carbo- and heterocyclic compounds via cycloaddition reactions.

References

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Autocatalytic alkylation of the cytochrome <i>P</i>-450 prosthetic haem group by 1-aminobenzotriazole. Isolation of an <i>NN</i>-bridged benzyne-protoporphyrin IX adduct

P.R. Ortiz de Montellano, James M. Mathews · Biochemical Journal · 1981 · 208 citations · Full text

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A New and Efficient Hypervalent Iodine−Benzyne Precursor, (Phenyl)[<i>o</i>-(trimethylsilyl)phenyl]iodonium Triflate:  Generation, Trapping Reaction, and Nature of Benzyne

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Absorptiometric and fluorimetric study of solvent dependence and prototropism of benzimidazole homologues

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