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The Quest for an Oxidative Coupling of Phenols and Indoles towards Benzofuroindolines: A Two-Stage Approach
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2014
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Combinatorial ChemistryBioorganic ChemistryEngineeringOrganic ChemistryChemistryHeterocycle ChemistryPolyphenolicsDiversity Oriented SynthesisBiosynthesisOxidative CouplingBenzofuroindoline MotifDerivativesBiochemistryDiversity-oriented SynthesisPharmacologyNatural Product SynthesisTwo-stage ApproachNatural SciencesIndoles Towards BenzofuroindolinesTwo-stage Sequence
The benzofuroindoline motif is found in several natural products and its biosynthesis is believed to be the oxidative coupling of phenols and indoles. A two-stage sequence has been developed to assemble these two units through the generation of electrophilic <i>N</i>-acetylindoles. A large number of benzofuroindolines were obtained by this strategy.