Proline-Mediated Enantioselective Construction of Tetrahydropyrans via a Domino Aldol/Acetalization Reaction

Abstract

Highly enantioselective synthesis of tetrahydropyrans was accomplished via a domino proline-mediated aldol reaction/intramolecular acetal formation from an aldehyde and inexpensive aqueous tetrahydro-2H-pyran-2,6-diol as a five-carbon unit.