Stereoselective Total Synthesisof (+)-Valienamine and (+)-4-<i>epi</i>-Valienamine viaa Ring-Closing Enyne Metathesis Protocol

Abstract

Stereoselective total synthesis of (+)-valienamine is reported utilizing Sharpless asymmetric dihydroxylation, diastereoselective Carreira alkynylation, and ring-closing enyne metathesis (RCEYM) as key steps from l-serine. A similar strategy is also reported for the first total synthesis of (+)-4-epi-valienamine.