Asymmetric Synthesis of All Stereoisomers of Isofagomine Using [2,3]-Wittig Rearrangement

Abstract

The asymmetric synthesis of all stereoisomers of isofagomine from 5-hydroxymethyl-3-piperidene 6, which was prepared by [2,3]-Wittig rearrangement of O-alkylstannylmethyl compound 5 derived from readily available chiral 3-hydroxypiperidene 4, is described.