Rhodium-Catalyzed [2+2+2] Cycloaddition of Alkynes for the Synthesis of Substituted Benzenes: Catalysts, Reaction Scope, and Synthetic Applications

Abstract

The transition-metal-catalyzed [2+2+2] cycloaddition of alkynes is a useful and atom-economical method for the synthesis of substituted benzenes. This comprehensive review covers the [2+2+2]-cycloaddition reactions catalyzed by rhodium complexes. Applications of the rhodium-catalyzed [2+2+2] cycloaddition in the synthesis of functional organic compounds are also described.