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One-Pot Four Component Synthesis of 4, 6-Disubstituted 3-Cyano-2- Pyridones in Polyethylene Glycol
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2010
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Ammonium AcetateEngineeringComponent SynthesisOrganic ChemistryPolyethylene Glycol-600CatalysisMolecular CatalysisChemistrySynthesis MethodOne-pot FourEthyl CyanoacetateSynthetic ChemistryEnantioselective SynthesisBiomolecular EngineeringPolyethylene Glycol
The reaction of ketone, aldehyde, ethyl cyanoacetate and ammonium acetate in polyethylene glycol-600 is reported. The reaction proceeds smoothly in the absence of catalyst to yield 2-Pyridones. Keywords: PEG, 2-pyridone, four components