Natural SciencesChemistryCatalysisOrganic ChemistryCatalytic MechanismsHeterocycle SynthesisOrganic SynthesisHeterocycle FunctionalizationOrganic Molecule SynthesisPalladium CatalystsPalladium-catalyzed Cross-coupling
The palladium-catalyzed reaction of olefins with PhI(OAc)2-TBAB system provides a novel, efficient, and highly selective bisfunctionalization strategy to introduce bromo and oxygen groups simultaneously. The substituents on the C=C bond control the regioselectivity of this reaction, which could be an effective supplement of bromohydroxylation in organic synthesis.