Synthesis of alicyclic <i>N</i>‐substituted 1,3‐amino alcohols via 1,3‐oxazines

Abstract

Abstract magnified image Alicyclic N ‐substituted 1,3‐amino alcohols 13‐18 were prepared in a facile way in a one‐pot procedure from 1,3‐oxazines 5‐8 in the presence of a ketone 9‐12 . The complex reaction involves palladium‐catalyzed reduction, debenzylation and/or transimination and further reduction.