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Sc(OTf)<sub>3</sub>, an Efficient Catalyst for Formation and Deprotection of Geminal Diacetates (Acylals); Chemoselective Protection of Aldehydes in Presence of Ketones
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1998
Year
Chemical EngineeringEngineeringAcetic AnhydrideBiochemistryNatural SciencesBiocatalysisCatalytic SynthesisScandium TriflateOrganic ChemistryGeminal DiacetatesCatalysisChemoselective ProtectionChemistryMolecular CatalysisEfficient CatalystAsymmetric CatalysisEnantioselective SynthesisBiomolecular Engineering
Scandium triflate (2 mol%) has been found to be an extremely efficient catalyst for the addition of acetic anhydride to both aromatic and aliphatic aldehydes. Deprotection of the resulting geminal diacetates (acylals) was achieved using the same catalyst in the presence of water.