Organic Letters · 2012 · 56 citations · 47 references
Natural SciencesChemistryCatalysisOrganic ChemistryCross-coupling ReactionsDiversity-oriented SynthesisHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisAlkylation ReactionsDiversity-oriented Heterocycle SynthesisHeterocycle FunctionalizationPalladium CatalystsPalladium-catalyzed Cross-couplingScopeTransition-metal-catalyzed Heterocycle Synthesis
Palladium-catalyzed direct alkynylations of heteroarenes were accomplished with inexpensive gem-dichloroalkenes as user-friendly electrophiles, which set the stage for a modular, step-economical synthesis of diversely decorated heteroaryl alkynes with ample scope.
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