Pyrroloiminoquinone Alkaloids: Discorhabdins and Makaluvamines

Abstract

The pyrroloiminoquinone alkaloid family consisting of discorhabdins and makaluvamines exhibits antitumor activities derived from their unique highly-fused structures. The total synthesis of them and the key reactions used in the total synthesis of these compounds are described. Keywords: discorhabdin c, yamamura's synthesis, heathcock's synthesis, white's formal synthesis, makaluvamine a, kraus's synthesis