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A Reductive Amination/Lactamization Procedure Using Borohydride Reagents
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1994
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EngineeringMild ConditionsOrganic ChemistryTandem Reductive AminationlactamizationNabh4/ MeohChemistryReagentStereoselective SynthesisAsymmetric CatalysisSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineering
We report a procedure for tandem reductive aminationlactamization of aldehydes or ketones with aminoesters or ketoesters with primary amines under mild conditions (NaBH(OAc)3/1,2-dichloroethane or NaBH4/ MeOH).