One-Pot Dry Media Synthesis of New Tetracyclic 1,5-Benzothiazepines under Microwave Activation

Abstract

Green chemical approaches to the condensation reaction of substituted benzenethiols and 2-arylidene-1-tetralone as synthons for the syntheses of a series of new 7-phenyl-5,6,6a,7-tetrahydrobenzo[b]naphtho[1,2-e][1,4]thiazepines (4a-e) of biological importance are described.The reaction using montmorillonite KSF as an inorganic solid is accelerated under microwave irradiation.Details and advantages of this new, efficient, solvent-free protocol along with non-thermal specific microwave effects are underlined.