Concepedia

Synthesis of Coumarines and 4<i>H</i>-Chromenes through the Reaction of<i>tert</i>-Butyl Isocyanide and Dialkyl Acetylenedicarboxylates in Presence of 2-Hydroxybenzaldehydes

Issa Yavari, Hoorieh Djahaniani, Farough Nasiri

Synthesis · 2004 · 45 citations · 0 references

Concepts

Medicinal ChemistryNatural Product SynthesisEffective RouteNatural SciencesOrganic ChemistryTert-butyl IsocyanideChemistryHeterocycle ChemistryPharmacologySynthetic ChemistryEnantioselective SynthesisDialkyl Acetylenedicarboxylates

Abstract

An effective route to novel coumarines and 4H-chromenes is described. This involves the reaction of tert-butyl isocyanide and dialkyl acetylenedicarboxylates in the presence of 2-hydroxybenzaldehydes.