Synthesis of (1<i>R</i>,4<i>R</i>)- and (1<i>S</i>,4<i>S</i>)-2,5-Diazabicyclo[2.2.1]heptanes and Their<i>N</i>-Substituted Derivatives

Abstract

Derivatives of the (1R,4R)- and (1S,4S)-2,5-diazabicyclo- [2.2.1]heptane ring system are prepared in enantiomerically pure form from trans-4-hydroxy-L-proline (2). The target compounds are precursors of antibacterial quinolone carboxyclic acids.