Advantage of Anaerobic Conditions in the Highly Enantioselective Synthesis of α,α-Dialkyl-α-Amino Acids by Chiral Phase-Transfer Catalysis

Abstract

Intervention of the enolate oxidation in the catalytic asymmetric phase-transfer alkylation of protected α-amino acid derivatives under aerobic conditions has been addressed, and anaerobic conditions have been introduced to obtain synthetically satisfactory chemical yields as well as a high level of enantioselectivity.