Antibiotic-Resistant <i>Acinetobacter baumannii</i> Is Susceptible to the Novel Iron-Sequestering Anti-infective DIBI <i>In Vitro</i> and in Experimental Pneumonia in Mice

Abstract

Acinetobacter baumannii is a major cause of nosocomial infections especially hospital-acquired pneumonia. This bacterium readily acquires antibiotic resistance traits and therefore, new treatment alternatives are urgently needed. The virulence of A. baumannii linked to iron acquisition suggests a potential for new anti-infectives that target its iron acquisition. DIBI, a 3-hydroxypyridin-4-one chelator, is a purpose-designed, iron-sequestering antimicrobial that has shown promise for treating microbial infection.