A Novel Trypsin‐Catalyzed Three‐Component <i>Mannich</i> Reaction

Abstract

Abstract We found that the trypsin from hog pancreas displayed high activity to promote three‐component Mannich reaction of aromatic aldehydes, aromatic amines, and acetone with moderate‐to‐excellent yields. The reaction tolerates a great range of substrates and extends the application of trypsin in organic synthesis.