General and Versatile Approach to the Synthesis of Optically Active 5- Alkylpiperazine-2-carboxylic Acids

Abstract

General and convenient syntheses of optically active 5-alkylpiperazine-2-carboxylic acids are described. The methods are based on cyclization of L- or D-serine with α-amino acids and occur without loss of optical purity. The presented procedures are based on readily available starting materials and can be arranged for multigram quantities.