Organic Letters · 2006 · 89 citations · 16 references
Natural SciencesChemistryMedicinal ChemistryCatalysisOrganic ChemistryCatalyst PreparationCatalyst SynthesisCross-coupling ReactionsHeterocycle SynthesisHeterocyclic ChemistryOrganic SynthesisHeck ReactionHeterocycle FunctionalizationIndole ChemistryIndole DerivativesIndole SynthesisPalladium CatalystsPalladium-catalyzed Cross-couplingThiophene Chemistry
A variety of di- and trisubstituted thiophenes were synthesized by a one-pot palladium-catalyzed ortho-alkylation sequence terminated by either Heck or C-H coupling. Initial results toward the functionalization of indoles are also presented.
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Palladium-Catalyzed Multiple Arylation of Thiophenes
Toru Okazawa, Tetsuya Satoh, Masahiro Miura et al. · Journal of the American Chemical Society · 2002 · 318 citations