The Power of High‐Throughput Experimentation in Homogeneous Catalysis Research for Fine Chemicals

TLDR

High‑throughput experimentation (HTE) enables rapid discovery of catalytic solutions, shortening time‑to‑market for fine‑chemical production. The authors aim to demonstrate HTE’s utility in lead generation, optimization, scope determination, and mechanistic studies for low‑cost aromatic substitution reactions and asymmetric hydrogenation. They employ HTE to generate leads, optimize reaction conditions, assess scope, and probe mechanisms in C–H activation, Heck, Suzuki, and asymmetric hydrogenation reactions. HTE allowed the rapid identification of catalytic solutions and mechanistic insights, accelerating development of fine‑chemical processes. © Wiley‑VCH Verlag GmbH & Co.

Abstract

Abstract The use of high‐throughput experimentation (HTE) in homogeneous catalysis research for the production of fine be found within a very short time frame. At the same time, a reliable process can be achieved because extensive time‐to‐market constraints, HTE allows catalytic solutions to be found within a very short time frame. At the same time, a reliable process can be achieved because extensive imisation can be undertaken. We give examples of lead generation and optimisation, and of scope determination, based on our basic research program aimed at developing low‐cost aromatic substitution reactions (C−H activation, Heck and Suzuki reactions). We also give an example of HTE in mechanistic research, which stems from our work on asymmetric hydrogenation with low‐cost monodentate phosphoramidite ligands. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)