Synlett · 2015 · 17 citations · 0 references
PharmacyChemistryMedicinal ChemistryDrug DiscoveryOrganic ChemistrySynthetic Medicinal ChemistryCross-coupling ReactionsNatural Product Drug DiscoveryChemical Library SynthesisChemoselective Library SynthesisCopper-catalyzed CouplingSmall-molecule Library Construction
The copper-catalyzed coupling of SF<sub>5</sub>-substituted potassium aryl trifluoroborates with amines and alcohols is reported. This method provides a simple access to novel 3-pentafluorosulfanyl-substituted anilines and aryl ethers, which are potential important building blocks for drug discovery and agrochemicals.