Sterically Hindered Bases. Synthesis of 2,4,6-Trisubstituted Pyrimidines

Abstract

A new method for the synthesis of sterically hindered pyrimidines 7 by the reaction of alkynes 5 with nitriles 6 in the presence of trifluoromethanesulfonic acid is described. The pKa*-values of some of the synthesized pyrimidines 7, which can be used as nonnucleophilic bases, were determined in 50% aqueous ethanol.