One-Pot Annulation of Pyrimidine Ring on Azoles Under Microwave Irradiation and Solvent-Free Conditions - Concepedia

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One-Pot Annulation of Pyrimidine Ring on Azoles Under Microwave Irradiation and Solvent-Free Conditions

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2003

Year

Lal Dhar S. Yadav, S. K. Singh

Chemical EngineeringMicrowave SynthesisEngineeringAcetic AnhydrideHeterocyclicPyrimidine RingOrganic ChemistryMicrowave IrradiationChemistryHeterocycle ChemistryPharmacologyOne-pot AnnulationSynthetic ChemistryAzole Schiff

Abstract

Azole Schiff bases 2a-f are annulated diastereoselectively with glycine and acetic anhydride, under microwave irradiation and solvent-free conditions, to yield 6,7-dihydro-5H-1,3,4-oxa(thia)diazolo[3,2-a]pyrimidin-5-ones 4a-f in a one-pot procedure.