Enantiotopic Synthesis of Natural Products: Merrilactone and Guanacastepene

Abstract

We have previously disclosed the total syntheses of racemic merrilactone A and guanacastepene A. We describe herein the development of new routes to key intermediates in the first-generation syntheses, which will allow us to access both merrilactone A and guanacastepene A in enantiomerically enriched form.