Antimicrobial Agents and Chemotherapy · 2018 · 23 citations · 22 references
Life SciencesInfectious DiseasesMicrobiologyAntimicrobial ResistanceInfection PreventionMedical MicrobiologyAntimicrobial TherapyBacterial BiofilmsBiofilm FormationBiofilm Formation In InfectionCatheter-associated Infection PreventionMicrobial BiofilmsAntimicrobial Lock TherapyBiofilm InhibitionCatheter Lock TherapyCatheter-associated BiofilmsCatheter-related Bloodstream Infection TreatmentCentral Line-associated Bloodstream InfectionsDrug-resistant PathogensIntravascular Catheter Infection Prevention
Central-line-associated bloodstream infections are increasingly recognized to be associated with intraluminal microbial biofilms, and effective measures for the prevention and treatment of bloodstream infections remain lacking. This report evaluates a new commercially developed antimicrobial catheter lock solution (ACL), containing trimethoprim (5 mg/ml), ethanol (25%), and calcium EDTA (Ca-EDTA) (3%), for activity against bacterial and fungal biofilms, using in vitro and in vivo (rabbit) catheter biofilm models.
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Leonard A. Mermel, Michael Allon, Emilio Bouza et al. · Clinical Infectious Diseases · 2009 · 3.6K citations · Full text