Synthesis and Antitumor Activity of 2-Aryl-7-fluoro-6-(4-methyl-1-piperazinyl)-4(3H)-quinazolinones

Abstract

A series of new 2-aryl-7-fluoro-6-(4-methyl-1-piperazinyl)-4(3H)quinazolinones were prepared by the oxidative cyclization of the corresponding 2-arylidineamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzamides.The new quinazolinones were evaluated for their antitumor activity.