Direct Conversion of p-Methoxybenzyl Ethers into Silyl-protected Alcohols by the Action of Trialkylsilyl Trifluoromethanesulfonate and Triethylamine

Abstract

The combined use of t-butyldimethylsilyl trifluoromethanesulfonate and triethylamine cleaves readily p- or o-methoxybenzyl ethers to give directly the corresponding t-butyldimethylsilyl ethers in high yields thus affording an expedient way to replace the benzyl ether-type protective group with the silyl ether-type one.