Publication | Closed Access
Asymmetric Dehydrative C-, N-, and O-Allylation Using Naph-diPIM-dioxo-i-Pr-CpRu/p-TsOH Combined Catalyst
30
Citations
0
References
2012
Year
Chemical EngineeringAsymmetric Dehydrative C-EngineeringCross-coupling ReactionBiochemistryNatural SciencesOrganic ChemistryOrganometallic CatalysisCatalysisMolecular CatalysisChemistryCatalyst PreparationBrønsted AcidAsymmetric CatalysisDehydrative Intermolecular C-allylationEnantioselective SynthesisCatalytic SynthesisIntramolecular C-
(<i>S</i>,<i>S</i>)- or (<i>R</i>,<i>R</i>)-Naph-diPIM-dioxo-<i>i</i>-Pr–CpRu(II) complex with a Brønsted acid catalyzes dehydrative intermolecular C-allylation with high enantio- and regioselectivity. The new soft Ru/hard H<sup>+</sup> combined catalyst can also be used for intramolecular C-, N-, and O-allylations, giving nearly enantiomerically pure α-alkenyl-substituted cyclic compounds. As water is only the co-product, the synthetic process can be readily scaled up.