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One-Pot Synthesis of DihydropyrimidinonesUsing Iodotrimethylsilane. Facile and New Improved Protocol forthe Biginelli Reaction at Room Temperature
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2003
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Room TemperatureChemical EngineeringEngineeringOne-pot SynthesisNovel OneOrganic ChemistryChemistrySynthesis MethodBiginelli ReactionPot CondensationSynthetic ChemistryEnantioselective SynthesisNatural Product Synthesis
A novel one pot condensation of an aldehyde, β-ketoester and urea has been performed using TMSI in acetonitrile for the first time at room temperature affording dihydropyrimidinones in excellent yields.