Intramolecular Friedel-Crafts Alkylation of Chalcone Epoxides Using Indium(III) Chloride as an Efficient Catalyst

Abstract

Indium(III) chloride catalyzes the ring opening of chalcone epoxides followed by intramolecular Friedel-Crafts alkylation under mild conditions at room temperature to afford highly functionalized 3-aryl-2-hydroxy-2,3-dihydro-1H-inden-1-ones in excellent yields (81-95%).