New, Efficient Approach for the Ligand-Free Suzuki–Miyaura Reaction of 5-Iodo-2′-deoxyuridine in Water

Abstract

A series of 5-aryl-2′-deoxyuridines was prepared, using ligandless Suzuki–Miyaura cross-coupling reactions in neat water, starting from 5-iodo-2′-deoxyuridine as totally deprotected starting material. This ligand-free process gave good to high isolated yields within short reaction times and with low loadings of palladium.