Triphenylphosphine catalyzed formation of functionalized 2‐aminothiophenes

Abstract

Abstract Triphenylphosphine was used as a nucleophilic catalyst in the addition–cyclization reaction of phenyl isothiocyanate with electron‐deficient allenes. This strategy offers a new approach for the synthesis of 2‐aminothiophenes under neutral conditions. © 2007 Wiley Periodicals, Inc. Heteroatom Chem 18:312–315, 2007; Published online in Wiley InterScience ( www.interscience.wiley.com ). DOI 10.1002/hc.20300