A Convenient Synthetic Method for Fully Conjugated 3-Alkyl- and 3-Aryl-5-trifluoromethyl-1-methyl-1,2-thiazine 1-Oxide from β-Alkoxyvinyl Trifluoromethyl Ketones

Abstract

A new series of 4-dimethylsulfoximide-1,1,1-trifluoro-3-buten-2-ones has been prepared by the direct reaction of 4-alkoxy-4-alkyl-(aryl)-1,1,1-trifluoro-3-buten-2-ones with S,S-dimethylsulfoximide, in good yields. The new 5-trifluoromethylated 3-alkyl- and 3-aryl-1-methyl-1,2-thiazine 1-oxide derivatives by intramolecular cyclization reactions have been easily isolated.