Publication | Closed Access
Ultrasound-accelerated Michael Addition of Indole to α,β-Unsaturated Ketones Catalyzed by Ceric Ammonium Nitrate (CAN)
71
Citations
0
References
2003
Year
Chemical EngineeringNovel OrganocatalystsEngineeringSonoelectrochemistrySonochemistryOrganic ChemistryCatalysisChemistryUltrasoundUltrasound-accelerated Michael AdditionCeric Ammonium NitrateUltrasonic IrradiationIndole NucleusSynthetic ChemistryEnantioselective SynthesisBiomolecular Engineeringβ-Unsaturated Ketones Catalyzed
Ceric ammonium nitrate efficiently catalyzes the Michael addition of indole to α,β-unsaturated carbonyl ketones by means of alkylation of indole under ultrasonic irradiation to afford the corresponding adduct in excellent yields. The substitution on the indole nucleus occurred exclusively at the 3-position, and N-alkylation products have not been observed.